Tuesday 2 October 2012

Fluconazole Suspension



Pronunciation: floo-KON-a-zole
Generic Name: Fluconazole
Brand Name: Diflucan


Fluconazole Suspension is used for:

Treating and preventing certain yeast and fungal infections. It may also be used for other conditions as determined by your doctor.


Fluconazole Suspension is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.


Do NOT use Fluconazole Suspension if:


  • you are allergic to any ingredient in Fluconazole Suspension

  • you have certain rare hereditary problems (glucose-galactose malabsorption, fructose intolerance, sucrase-isomaltase deficiency)

  • you are taking astemizole, cisapride, clopidogrel, an ergot alkaloid (eg, ergotamine), erythromycin, pimozide, quinidine, terfenadine, or voriconazole

Contact your doctor or health care provider right away if any of these apply to you.



Before using Fluconazole Suspension:


Some medical conditions may interact with Fluconazole Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have had an allergic reaction to another azole antifungal (eg, itraconazole)

  • if you have a history of liver or kidney problems, or heart problems (eg, irregular heartbeat, structural heart problems)

  • if you have a weakened immune system, HIV infection, diabetes, cancer, or blood electrolyte problems (eg, low blood potassium or magnesium levels)

Some MEDICINES MAY INTERACT with Fluconazole Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Antiarrhythmics (eg, amiodarone, quinidine, sotalol), arsenic, astemizole, cisapride, domperidone, macrolide antibiotics (eg, erythromycin), pimozide, quinolones (eg, levofloxacin), serotonin (5-HT1) receptor agonists (eg, eletriptan), terfenadine, or vandetanib because the risk of severe irregular heartbeat (eg, QT prolongation) may be increased

  • Rifabutin because the risk of certain eye problems (eg, uveitis) may be increased

  • Macrolide immunosuppressants (eg, sirolimus, tacrolimus) because the risk of kidney problems may be increased

  • Proton pump inhibitors (PPIs) (eg, omeprazole) or rifamycins (eg, rifampin) because they may decrease Fluconazole Suspension's effectiveness

  • Clopidogrel, hormonal birth control (eg, birth control pills), or losartan because their effectiveness may be decreased by Fluconazole Suspension

  • Amphotericin B, anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam, midazolam), buspirone, certain calcium channel blockers (eg, amlodipine, felodipine, nifedipine), carbamazepine, colchicine, cyclophosphamide, cyclosporine, eplerenone, ergot alkaloids (eg, ergotamine), everolimus, fentanyl, halofantrine, haloperidol, certain HMG-CoA reductase inhibitors or "statins" (eg, atorvastatin, fluvastatin, simvastatin), hydantoins (eg, phenytoin), lurasidone, methadone, muscarinic antagonists (eg, solifenacin, tolterodine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen), prednisone, ramelteon, ranolazine, sulfonylureas (eg, glipizide, glyburide, tolbutamide), theophylline, tolvaptan, tretinoin, tricyclic antidepressants (eg, amitriptyline), vinca alkaloids (eg, vinblastine, vincristine), voriconazole, or zidovudine because the risk of their side effects may be increased by Fluconazole Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fluconazole Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Fluconazole Suspension:


Use Fluconazole Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Fluconazole Suspension by mouth with or without food.

  • Shake well before each use.

  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

  • Take Fluconazole Suspension at least 2 hours before taking a PPI (eg, omeprazole).

  • To clear up your infection completely, take Fluconazole Suspension for the full course of treatment. Keep taking it even if you feel better in a few days. Do not miss any doses.

  • Fluconazole Suspension works best if it is taken at the same time each day.

  • If you miss a dose of Fluconazole Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Fluconazole Suspension.



Important safety information:


  • Fluconazole Suspension may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Fluconazole Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Fluconazole Suspension has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by Fluconazole Suspension has not been attributed to total daily dose, length of therapy, or sex or age of the patient. This type of liver damage may or may not be reversible when Fluconazole Suspension is stopped. Contact your doctor right away if you experience dark urine, loss of appetite, pale stools, severe stomach pain, or yellowing of the skin or eyes.

  • If your symptoms do not get better within a few days or if they get worse, check with your doctor.

  • Fluconazole Suspension only works against fungi; it does not treat viral infections (eg, the common cold) or bacterial infections.

  • Tell your doctor or dentist that you take Fluconazole Suspension before you receive any medical or dental care, emergency care, or surgery.

  • Be sure to use Fluconazole Suspension for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

  • If you develop a rash while you take Fluconazole Suspension, contact your doctor.

  • Long-term or repeated use of Fluconazole Suspension may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

  • Hormonal birth control (eg, birth control pills) may not work as well while you are using Fluconazole Suspension. To prevent pregnancy, use an extra form of birth control (eg, condoms).

  • Lab tests, including liver and kidney function, may be performed while you use Fluconazole Suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

  • Use Fluconazole Suspension with caution in the ELDERLY; they may be more sensitive to its effects.

  • PREGNANCY and BREAST-FEEDING: Fluconazole Suspension may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Fluconazole Suspension while you are pregnant. Fluconazole Suspension is found in breast milk. If you are or will be breast-feeding while you use Fluconazole Suspension, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Fluconazole Suspension:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Changes in taste; diarrhea; dizziness; headache; indigestion; mild stomach pain; nausea; vomiting.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness; wheezing); burning, numbness, or tingling; dark urine; fever, chills, or persistent sore throat; irregular heartbeat; loss of appetite; muscle pain, weakness, or cramping; pale stools; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea, nausea, or vomiting; swelling of the hands; unusual bruising or bleeding; unusual or severe stomach pain; unusual tiredness; yellowing of the eyes or skin.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Fluconazole side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include changes in behavior; hallucinations.


Proper storage of Fluconazole Suspension:

Store the unmixed dry powder in the original container, below 86 degrees F (30 degrees C). Store the mixed suspension in the original container, between 41 and 86 degrees F (5 and 30 degrees C), and discard the unused portion after 2 weeks. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fluconazole Suspension out of the reach of children and away from pets.


General information:


  • If you have any questions about Fluconazole Suspension, please talk with your doctor, pharmacist, or other health care provider.

  • Fluconazole Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Fluconazole Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Fluconazole resources


  • Fluconazole Side Effects (in more detail)
  • Fluconazole Use in Pregnancy & Breastfeeding
  • Drug Images
  • Fluconazole Drug Interactions
  • Fluconazole Support Group
  • 40 Reviews for Fluconazole - Add your own review/rating


Compare Fluconazole with other medications


  • Blastomycosis
  • Bone Marrow Transplantation
  • Candida Infections, Systemic
  • Candida Urinary Tract Infection
  • Chronic Mucocutaneous Candidiasis
  • Coccidioidomycosis
  • Coccidioidomycosis, Meningitis
  • Cryptococcal Meningitis, Immunocompetent Host
  • Cryptococcal Meningitis, Immunosuppressed Host
  • Cryptococcosis
  • Esophageal Candidiasis
  • Fungal Infection Prophylaxis
  • Fungal Infection, Internal and Disseminated
  • Fungal Peritonitis
  • Fungal Pneumonia
  • Histoplasmosis
  • Onychomycosis, Fingernail
  • Onychomycosis, Toenail
  • Oral Thrush
  • Tinea Versicolor
  • Vaginal Yeast Infection

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